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KMID : 0357920120460050478
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Korean Journal of Pathology
2012 Volume.46 No. 5 p.478 ~ p.482
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Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report
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Zhu Zhi-Yu
Chu Zhi-Gang
Chen Yu
Zhang Wei-Ping
Lv Di
Geng Ning
Yang Ming-Zhong
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Abstract
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Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.
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KEYWORD
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Ghost cell odontogenic carcinoma, Calcifying cystic odontogenic tumor
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